Our editors pick the 50 companies that best combine innovative technology with an effective business model.

1. Amazon

• Headquarters Seattle, Washington
• Industry Internet & Digital Media
• Status Public
• Valuation $ 337 billion

2. Baidu

• Headquarters Beijing, China
• Industry Internet & Digital Media
• Status Public
• Valuation $ 55 billion

3. Illumina

• Headquarters San Diego, California
• Industry Biotech
• Status Public
• Valuation $ 20 billion

4. Tesla Motors

• Headquarters Palo Alto, California
• Industry Transportation
• Status Public
• Valuation $ 28 billion

5. Aquion Energy

• Headquarters Pittsburgh, Pennsylvania
• Industry Energy
• Status Private
• Valuation Valuation not available, $ 190 million raised

6. Mobileye

• Headquarters Jerusalem, Israel
• Industry Computing & Communications
• Status Public
• Valuation $ 8 billion

7. 23andMe

• Headquarters Mountain View, California
• Industry Biotech
• Status Private
• Valuation $ 1.1 billion valuation

8. Alphabet

• Headquarters Mountain View, California
• Industry Internet & Digital Media
• Status Public
• Valuation $ 491 billion

9. Spark Therapeutics

• Headquarters Philadelphia, Pennsylvania
• Industry Biotech
• Status Public
• Valuation $ 918 million

10. Huawei

• Headquarters Shenzhen, China
• Industry Computing & Communications
• Status Private
• Valuation Valuation not available